Most armadillo damage occurs as a result of their rooting in lawns, golf courses, vegetable gardens, and flower beds. Characteristic signs of armadillo activity are shallow holes, 1 to 3 inches deep and 3 to 5 inches wide, which are dug in search of food. They also uproot flowers and other ornamental plants. Some damage has been caused by their burrowing under foundations, driveways, and other structures. Some people complain that armadillos keep them awake at night by rubbing their shells against their houses or other structures.
There is evidence that armadillos may be responsible for the loss of domestic poultry eggs. This loss can be prevented through proper housing or fencing of nesting birds.
Disease is a factor associated with this species. Armadillos can be infected by the bacterium Mycobacterium leprae, the causative agent of leprosy. The role that armadillos have in human infection, however, has not yet been determined. They may pose a potential risk for humans, particularly in the Gulf Coast region.